ENVIRONMENT DIRECTORATE
JOINT MEETING OF THE CHEMICALS COMMITTEE AND
THE WORKING PARTY ON CHEMICALS, PESTICIDES, AND BIOTECHNOLOGY
(Fullerenes C60 Summary of the Dossier – French IOMC).
Series on the Safety of Manufactured Nanomaterials No. 69
01-Jul-2016 ENV/JM/MONO(2016)21
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Dermal
An acute dermal toxicity study is not available; however, in two skin irritation studies, no deaths or abnormal findings were observed in male rabbits applied 0.5 g of fullerenes C60 (Nanom Purple) with 0.5 g of olive oil, 0.02 g fullerenes wetted with 0.2 ml of vehicle (direct application) or 0.5 ml of 20% fullerenes C60 suspension (see 4.1.3 skin irritation for further detail). Acute dermal toxicity was considered to be low.
Oral
An acute oral toxicity study is not available; however, in a repeated oral test of C60 (Nanom Purple)nanoparticles, no deaths were observed up to 1000 mg/kg BW/day (the highest dose) (see 4.1.5 repeated dose toxicity for further detail). Based on this finding, the LD50 for oral toxicity was considered to be greater than 1000 mg/kg-BW in rats. Moreover, in an in vivo micronucleus study of C60 nanoparticles using mice, no death or indicative of abnormality was observed up to 88 mg/kg BW/day (the highest dose) (see 4.1.6 mutagenicity for further detail).
(Fullerenes C60 Summary of the Dossier – French IOMC).